The Asunción campus is located in a prime urban area (Av. San Martín and Av. España), offering a sophisticated academic environment.

• Center for Medical Simulation (CESIMUP): UP Asunción houses one of the most advanced medical simulation centers in the country, where students practice clinical skills on high-fidelity simulators before seeing real patients.

• Laboratories: Includes cutting-edge labs for Biochemistry, Histology, and a renowned Anatomy lab with real specimens and digital 3D visualization.

• Faculty: Many professors are top-tier medical specialists practicing in the capital’s major hospitals.

As the capital city, Asunción provides the most diverse and high-volume clinical training in Paraguay.

• Public-Private Partnerships: UP has strong agreements with the Ministry of Public Health and social security hospitals (IPS).

• Clinical Rotations: Students rotate through major tertiary hospitals in the capital, such as the Hospital de Trauma and the Hospital Barrio Obrero.

• Exposure: Students gain experience in advanced specialties, including cardiology, neurosurgery, and high-complexity pediatrics, which may be less common in border cities.

As the premium campus in the capital, fees are slightly higher than the PJC campus:

• Enrollment Fee (Matrícula): Approx. $400 – $550 USD (per semester).

• Monthly Tuition: Approx. $450 – $650 USD (roughly 3.5M to 4.8M Guaraníes).

• Annual Total: Roughly $5,500 – $7,500 USD.

• Payment Plans: The university offers various "becas" (scholarships) and financial aid for students with excellent academic records.

• Capital Lifestyle: As the political and cultural capital, it offers the best shopping malls, cinemas, and nightlife in the country.

• Climate: Very hot and humid summers (often exceeding 40°C) and mild, pleasant winters.

• Safety: The university area (Villa Morra/San Martín) is considered one of the safest and most modern parts of the city.

• Logistics: International airport (Silvio Pettirossi) provides direct flights to major South American hubs and easy connections for international students.

• NRI Admissions: Admission is open to Indian/International students without an entrance exam, but NEET qualification is mandatory for those who wish to return to India.

• Documents: Requires Apostilled High School Diploma, Transcripts, Birth Certificate, and a clean Criminal Record (PCC).

• Legal Support: The university has a dedicated International Relations office to assist with the Temporary Residence permit process.